The Los Angeles Rams already have clinched a playoff berth for the fourth time in five seasons thanks to a five-game winning streak that has followed a string of three straight losses. They still have something for which to play in their final regular-season contest, as a third NFC West crown in five years under coach Sean McVay is within their grasp. The Rams (12-4) can capture that crown with a victory when they host the division-rival San Francisco 49ers (9-7) on Sunday. Los Angeles also would win the NFC West if Arizona loses at home to Seattle, while San Francisco will secure a wild-card spot if it defeats the Rams or New Orleans loses at Atlanta.

Kickoff from SoFi Stadium is set for 4:25 p.m. ET. Los Angeles is a 4.5-point favorite in the latest Rams vs. 49ers odds from Caesars Sportsbook, while the over-under for total points scored is 44.5. Before locking in any 49ers vs. Rams picks, make sure you check out the latest NFL predictions and betting advice from SportsLine’s proven projection model.

The model, which simulates every NFL game 10,000 times, is up over $7,200 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 18 of the 2021 season on an incredible 135-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Rams vs. Niners on Sunday and just revealed its NFL Week 18 picks and predictions. You can visit SportsLine now to see the model’s picks. Here are the NFL odds and betting lines for Niners vs. Rams:

Rams vs. 49ers spread: Los Angeles -4.5 Rams vs. 49ers over-under: 44.5 points Rams vs. 49ers money line: Los Angeles -220, San…..


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