The Indianapolis Colts and New England Patriots come in hot and rested for their NFL Week 15 matchup on Saturday at Indy’s Lucas Oil Stadium. Both teams come in off their bye weeks, and the Colts (7-6) have won four of their past five and are averaging more than 34 points over that span. Running back Jonathan Taylor has emerged as the NFL’s rushing leader and had 143 yards in a 31-0 rout of the Texans two weeks ago. The Patriots (9-4) have won seven in a row, beating the Bills 14-10 on Monday Night Football in Week 13. Rookie quarterback Mac Jones and New England’s offense are mostly staying out of the way and letting the league’s top scoring defense win games.

Kickoff from Indianapolis is set for 8:20 p.m. ET. Indianapolis is a 2.5-point favorite in the latest Patriots vs. Colts odds from Caesars Sportsbook, while the Over-Under for total points scored is 45. Before you make any Colts vs. Patriots picks, you need to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has broken down Saturday night’s Colts vs. Patriots matchup from every angle and just released its picks and predictions. You can head to SportsLine now to see the model’s picks. Here are some betting lines and trends for Patriots vs. Colts:

Patriots vs. Colts spread: Indianapolis -2.5¬†Patriots vs. Colts: 45 points¬†Patriots vs. Colts money line: New…..

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