We’re in the home stretch of the 2021 season with just four weeks remaining. Week 15 promises to paint a clearer picture of who may still be kicking by the time the year comes to a close as seven teams have an opportunity to punch their ticket into the postseason in this coming slate. Of course, you’re here to get an inside track of who has the best shot at coming out on top in Week 15 to keep you betting sharp. And you’ve come to the right place

Each week, we’ll collect all of the best picks and gambling content from CBSSports.com and SportsLine in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more.

All NFL odds via Caesars Sportsbook.

Which picks can you make with confidence in Week 15? And which Super Bowl contender goes down hard? Visit SportsLine, as their incredible model simulates every NFL game 10,000 times and is up almost $7,000 for $100 players on top-rated NFL picks since its inception six years ago.

Patriots at Colts

Time: Saturday, 8:15 p.m. ET (NFL Network), stream on fuboTV (try for free) 
Open: Patriots -1
Current: Colts -2.5

“Heading into Week 15, the Colts are 7-6 on the season, but here’s the key part: They’re 7-0 when they rush for more than 125 yards in a game and 0-6 when they rush for less than 125, so all you have to do is figure out whether they’re going to rush for 125 yards against the Patriots. My gut says no. 

“As we know, Bill Belichick tries to take away the thing you do best and the thing Indy does best is run the ball. Belichick is going to take away the run and make Carson Wentz beat him and based on what I’ve seen from Carson Wentz this season, I have a better chance of defusing a small bomb using a shot glass than Wentz does of…

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