49ers vs. Rams odds, spread, line: Monday Night Football picks, predictions from NFL model on 128-88 run

Matthew Stafford and the Los Angeles Rams (7-2) will travel to Levi’s Stadium to take on Jimmy Garoppolo and the San Francisco 49ers (3-5) on Monday Night Football. The Rams had their four-game win streak snapped with a loss to the Tennessee Titans in Week 9. Los Angeles is currently second in the NFC West behind the Arizona Cardinals. The 49ers are looking to get back on track and pick up their first divisional win of the season.

Kickoff from Levi’s Stadium is set for 8:20 p.m. ET. Los Angeles is favored by 3.5 points in the latest 49ers vs. Rams odds from Caesars Sportsbook, while the Over-Under is 50.5. Before locking in your Rams vs. 49ers picks, make sure you check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up!

Now, the model has simulated Rams vs. 49ers 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for 49ers vs. Rams:

49ers vs. Rams spread: Rams -3.549ers vs. Rams over-under: 50.5 points 49ers vs. Rams money line: LAR -190, SF +160 LAR: Under has hit in three of Rams’ last five gamesSF: 49ers are 13-4 against the spread in their last 17 Monday games

Featured Game | San Francisco 49ers vs. Los Angeles Rams


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