Week 16 NFL picks, odds, 2021 best bets from proven model: This five-way football parlay would pay out 25-1

The top two picks in the 2021 NFL Draft will square off when Trevor Lawrence and the Jacksonville Jaguars take on Zach Wilson and the New York Jets on Sunday at MetLife Stadium. Lawrence, the No. 1 overall pick, and Wilson, who went No. 2, have struggled this season, as their teams have gone a combined 5-23. In the latest NFL odds from Caesars Sportsbook, the Jets are favored by two.

The game is one of 16 on a full Week 16 NFL schedule. Other key matchups include the Patriots and Bills battling for the lead in the AFC East and the Bengals and Ravens squaring off for first place in the AFC North. Before making any 16 NFL bets or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 16. If you successfully parlay its picks, you’d be looking at a massive payout of 25-1. You can only see the model’s Week 16 NFL picks at SportsLine. 

Top Week 16 NFL picks

After simulating every game 10,000 times, the model is high on the Saints to cover as three-point favorites on Monday Night Football against the Miami Dolphins. Rookie quarterback Ian Book is set to make his first NFL start and regular-season debut for New Orleans (7-7), which will be without both Taysom Hill and Trevor Siemian (reserve/COVID list). Tua Tagovailoa will start for Miami (7-7), which has…

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