Saints vs. Bills odds, line: 2021 Thanksgiving Day NFL picks, predictions from top model on 130-91 roll

The Buffalo Bills (6-4) will visit the New Orleans Saints (5-5) to cap off the 2021 Thanksgiving Day NFL schedule. The Bills have been up and down over the past four weeks, alternating wins and losses, and fell to second place in the AFC East. New Orleans is currently on a three-game losing streak, but still has a chance to make the NFL playoff picture.

Kickoff from Caesars Superdome is set for 8:20 p.m. ET. Buffalo is favored by 6.5 points in the latest Saints vs. Bills odds from Caesars Sportsbook, while the Over-Under is 45. Before locking in your Bills vs. Saints picks, check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Bills vs. Saints 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting trends for Bills vs. Saints:

Bills vs. Saints spread: Buffalo -6.5Bills vs. Saints over-under: 45 pointsBills vs. Saints money line: Buffalo -270, New Orleans +220BUF: Bills are 4-0-1 against the spread in their last five games following an ATS lossNO: Under is 8-0-1 in Saints’ last nine Thursday games 

Why the Bills can cover

Buffalo rolls into this matchup with the No. 1 ranked defense in the NFL. They allow 283.7 yards per game with 17.6 points per game. This unit hasn’t given up over 300 yards passing in any matchup this…

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