Ohio State vs. Michigan State odds, line: 2021 college football picks, Week 12 predictions from proven model

It’s a game with major College Football Playoff implications when the No. 4 Ohio State Buckeyes host the seventh-ranked Michigan State Spartans on Saturday. The Buckeyes (9-1, 7-1 Big Ten) have won eight straight games and have the nation’s highest-scoring offense. Michigan State (9-1, 6-1) followed an emotional victory against rival Michigan with a stunning loss to Purdue two weeks ago, but it bounced back with a 40-21 win against Maryland last week. The Buckeyes beat that same Purdue team 59-31 last Saturday. Ohio State has beaten the Spartans five straight times, including a 52-12 drubbing in East Lansing last season.

Kickoff from Ohio Stadium in Columbus is set for noon ET. The Buckeyes are the 19-point favorites in the latest Michigan State vs. Ohio State odds from Caesars Sportsbook, while the over-under for total points scored is 68.5. Before making any Ohio State vs. Michigan State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has locked in on Ohio State vs. Michigan State and just revealed its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Here are the CFB odds and betting lines for Michigan State vs. Ohio State:  

Ohio St. vs. Michigan St. spread: Buckeyes -19 Ohio St. vs. Michigan St. over-under: 68.5…..

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