NFL odds, lines, picks, spreads, bets, top predictions for Week 10, 2021: Model loving Bills, Broncos

One of the most shocking results of the first half of the NFL season saw the Bills losing to the Jaguars last week. Those teams are now part of the two largest Week 10 NFL spreads according to Caesars Sportsbook. Buffalo is a 13-point favorite as it looks to rebound against the Jets, while Jacksonville’s victory didn’t do much to shift its prospects in the eyes of oddsmakers. The Jags are 10.5-point underdogs in the latest Week 10 NFL odds as they travel to Indianapolis to take on the Colts.

Was last week’s Bills vs. Jaguars game an aberration for both teams? Or, was it a sign of life to come, causing you to adjust your Week 10 NFL bets? All of the Week 10 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 10 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 10 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 10 NFL predictions

One of the model’s strongest Week 10 NFL picks is that the Bills (-13) cover the spread against the Jets. Despite Buffalo’s Week 9 defeat, the model is looking at its full body of work. The Bills lead the NFL in scoring defense and are fourth in scoring offense, while the Jets rank among the bottom six in both. Buffalo has also always bounced back after losses, as it has outscored its two…


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