NFL odds, lines, picks, spreads, bets, top predictions for Week 10, 2021: Model backing Bills, Broncos

The loss of star running back Derrick Henry did not stop Tennessee from winning its fifth consecutive game last week, including its fourth straight in upset fashion. The Titans pulled off a 28-16 win at Los Angeles as seven-point underdogs and will try to extend their winning streak to six games when they host New Orleans as part of the Week 10 NFL schedule. Caesars Sportsbook lists Tennessee as a 2.5-point home favorite in the latest Week 10 NFL odds. Will the Titans continue to surprise oddsmakers or can New Orleans notch a road win and beat one of the smallest NFL spreads of the week?

Elsewhere in the NFL Vegas odds, Indianapolis is a 10.5-point favorite against Jacksonville. The Colts are three games back of Tennessee in the division standings, so they cannot afford a loss. All of the Week 10 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 10 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 10 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 10 NFL predictions

One of the model’s strongest Week 10 NFL picks is that the Bills (-12) cover the spread against the Jets. Buffalo is coming off a head-scratching loss to Jacksonville last week, as the offense was unable to score a touchdown in a 9-6 final. New England…


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