A wave of COVID-19 outbreaks among NFL teams over the past few weeks is making the job of setting a lineup for the fantasy football playoffs even more difficult. Fantasy managers may not know until game time whether or not some of their key players will be available.

Kansas City Chiefs quarterback Patrick Mahomes, for example, could be without his top two receivers in Tyreek Hill and Travis Kelce.

Fantasy football rankings for Week 16 are based on the point-per-reception (PPR) scoring used in most seasonal and daily fantasy football formats. One point is awarded for every 10 rushing and receiving yards and one point for every 20 passing yards. Six points are awarded for touchdowns scored, four points for passing TDs and one point for receptions.

Rankings are compiled by FantasySharks.com.

(*- Be sure to check injury/status before kickoff)

Quarterback Patrick Mahomes may not have all of his weapons on offense this week with the Chiefs dealing with a COVID outbreak.

QUARTERBACKS

1 Patrick Mahomes K.C. vs. Pit.

2 Justin Herbert L.A.-C at Hou.

3 Tom Brady T.B. at Car.

4 Kyler Murray Ari. vs. Ind.

5 Dak Prescott Dal. vs. Was.

6 Matthew Stafford L.A.-R at Min.

7 Russell Wilson Sea. vs. Chi.

8 Josh Allen Buf. at N.E.

9 Aaron Rodgers G.B. vs. Cle.

10 Jalen Hurts Phi. vs. N.Y.-G

11 Joe Burrow Cin. vs. Bal.

12 Lamar Jackson Bal. at Cin.

13 Derek Carr L.V. vs. Den.

14 Ryan Tannehill Ten. vs. S.F.

15 Tua Tagovailoa Mia. at N.O.

16 *Kirk Cousins Min. vs. L.A.-R

17 Taysom Hill N.O. vs. Mia.

18 Cam Newton Car. vs. T.B.

19 Matt Ryan Atl. vs. Det.

20 Jimmy Garoppolo S.F. at Ten.

21 Davis Mills Hou. vs. L.A.-C

22 Justin Fields Chi. at Sea.

23 Ben Roethlisberger Pit. at K.C.

24 Carson Wentz Ind. at Ari.

25 *Tyler Huntley Bal. at Cin.

26 Trevor Lawrence Jac. at N.Y.-J

27 Mac Jones N.E. vs. Buf.

28 Zach Wilson N.Y.-J vs. Jac.

29 *Jake Fromm N.Y.-G at Phi.

30 Drew Lock Den. at L.V.

31 *Jared Goff Det. at Atl.

32 *Nick Mullens Cle. at G.B.

RUNNING BACKS

1 Jonathan Taylor Ind. at Ari.

2 Dalvin Cook Min. vs. L.A.-R

3 Alvin…

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