Colts vs. Buccaneers odds, line: 2021 NFL picks, Week 12 predictions from proven computer model

The Tampa Bay Buccaneers will take on the Indianapolis Colts at 1 p.m. ET on Sunday at Lucas Oil Stadium. Indianapolis is 6-5 overall and 3-3 at home, while the Buccaneers are 7-3 overall and 2-3 on the road. Tampa Bay avoided a third straight loss in Week 11. The Colts have won five of their last six games. 

Buccaneers coach Bruce Arians is 3-0 vs. the Colts. Tampa Bay is favored by three points in the latest Colts vs. Buccaneers odds from Caesars Sportsbook, and the over-under is set at 53. Before entering any Buccaneers vs. Colts picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Colts vs. Buc. You can head to SportsLine to see its picks. Here are several NFL betting lines for Bucs vs. Colts:

Colts vs. Buccaneers spread: Colts +3Colts vs. Buccaneers over-under: 53 points

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