College football picks, schedule: Predictions against the spread, odds for top 25 games today in Week 12

Both conference and College Football Playoff championship races are ramping up as the 2021 regular season gets closer to its conclusion. There’s no conference in which separation is potentially greater than the Big Ten, and two of the titans from the East Division in the conference with CFP aspirations are set to square off on Saturday in a marquee top-10 showdown here in Week 12. 

The day begins with No. 7 Michigan State going on the road to Columbus to face a No. 4 Ohio State team that’s really seemed to find its offensive rhythm of late. The Buckeyes are significant favorites because of that offensive attack as well as the Spartans’ poor passing defense. Michigan State, however, enters with a massive chip on its shoulder. This is a team that feels disrespected by the CFP committee in being ranked behind No. 6 Michigan — a team it defeated this season. However, an upset win over the Buckeyes in Columbus would surely earn the Spartans the respect to which they feel entitled. 

Also in the spotlight Saturday is No. 2 Alabama, which can clinch the SEC West title and set up the most anticipated matchup of the 2021 season in the conference title game on Saturday, Dec. 4 with No. 1 Georgia with a win over no. 21 Arkansas. In the nightcap of the evening, No. 3 Oregon will look to boost its resume with a victory on the road against a tough No. 24 Utah squad. 

While winning is all that matters for the standings, we care about whether these teams will cover their spreads. Be sure to stick with CBS Sports throughout the day for college football coverage from the opening kickoff onward. Let’s take a look at our expert picks for the 12th full Saturday of the season.

Odds via Caesars Sportsbook | All times Eastern

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