The surging Indianapolis Colts will try to move closer to a postseason bid when they take on the reeling Arizona Cardinals in a key 2021 NFL Christmas Day matchup. The Colts (8-6) have been on a roll, winning two in a row and five of six, including last week’s 27-17 win over the New England Patriots, a team Indianapolis had not beaten since 2009. The Cardinals (10-4), who lead the NFC West by a tiebreaker over the Los Angeles Rams, have dropped two consecutive games and four of their past seven following a 7-0 start to the season. This will be the first meeting between the teams since 2017, when the Cardinals defeated the Colts 16-13 in overtime at Indianapolis.

Kickoff from State Farm Stadium in Glendale, Ariz., is set for 8:15 p.m. ET. Arizona is a 2.5-point favorite in the latest Cardinals vs. Colts odds from Caesars Sportsbook, while the over-under for total points scored is 48.5. Before you make any Colts vs. Cardinals bets, make sure to check out the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Colts vs. Cardinals 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting trends for Colts vs. Cardinals:

Colts vs. Cardinals spread: Cardinals -2.5Colts vs. Cardinals over-under: 48.5 pointsColts vs. Cardinals…..

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